Importance of circulating microRNA-122 for hepatocellular carcinoma
نویسندگان
چکیده
Purpose: The main purpose of our study is to research the potential circulating microRNA-122 (miR-122)as a marker for hepatocellular carcinoma.
 Materials and Methods: Circulating miR-122 levels were measured by real-time polymerase chain reaction in patients with varied stages carcinoma. In addition, various other laboratory clinical data participants evaluated order observe correlation between these serum levels.
 Results: Serum found significantly higher carcinoma compared control group. (median (min. – max.); patients: 0.0104 (0-0.262); controls: 0.00187 (0-0.100), p
منابع مشابه
Circulating microRNA-122a as a diagnostic marker for hepatocellular carcinoma
BACKGROUND The purpose of this study was to evaluate the potential value of circulating miRNA-122a and miRNA-221 in the diagnosis of hepatocellular carcinoma. METHODS Serum samples were obtained from 85 patients with hepatocellular carcinoma and 85 age-matched and sex-matched healthy volunteers. miRNAs were isolated from the serum samples, and alfa-fetoprotein levels were determined. Expressi...
متن کاملThe role of circulating microRNA in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a rapidly progressing disease that exerts a huge burden on patients and health care systems. Rapid progression and difficulty in detecting early disease are major obstacles in offering potentially curative treatments. Besides the lack of effective chemo- or immunotherapy for advanced disease, there are currently no reliable tumor markers or imaging technologies...
متن کاملCirculating microRNA-200 Family as Diagnostic Marker in Hepatocellular Carcinoma
GOALS In this clinical study, we aimed to evaluate the role of circulating microRNA-200 family as a non-invasive tool to identify patients with cirrhosis-associated hepatocellular carcinoma (HCC). BACKGROUND Prognosis of HCC remains poor with increasing incidence worldwide, mainly related to liver cirrhosis. So far, no reliable molecular targets exist for early detection of HCC at surgically ...
متن کاملCirculating microRNA-122 as a potential biomarker for liver injury.
Liver-specific microRNA-122 (miR-122) is involved in the replication of hepatitis C virus (HCV) and its potential as a target for antiviral intervention was recently assessed. However, the use of circulating miR-122 in the evaluation of liver function has never been reported. In the present study, changes of serum miRNA levels were first evaluated in acute human hepatotoxicity due to paraquat e...
متن کاملRegulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.
Distal-less 4 (DLX4) is a member of the DLX family of homeobox genes. Recent reports have suggested that abnormal expression of DLX4 is present in several types of human tumors, including breast cancer, leukemia and colon cancer. However, the function and the mechanistic regulation of DLX4 in hepatocellular carcinoma (HCC) are elusive. In the present study, a proportion of hepatocellular carcin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cukurova Medical Journal
سال: 2021
ISSN: ['2602-3040', '2602-3032']
DOI: https://doi.org/10.17826/cumj.934776